AI creates molecules not found in nature that can alter human genes to cure even the rarest of diseases

AI is used to compose music, suggests recipes and make investment decisions, but a company has designed a system that can edit human genes.

California-based Profluent Bio developed a system capable of creating a range of bespoke cures for disease by developing molecules that have never existed in nature.

DailyMail.com spoke to Ali Madani, CEO of Profluent Bio, who said the AI-made gene editors have been tested in human cells, which demonstrated high levels of functionality while not editing unintended sites in the DNA.

The AI was trained on a database of 5.1 million CRISPR-associated (Cas) proteins, allowing it to create potential molecules that could be used in gene editing.

The system then narrowed down the results to four million sequences, allowing it to identify the gene editor the team named OpenCRISPR-1. 

Experiments showed OpenCRISPR-1 performed as well as Cas proteins, but it also reduced the impact on off-target sites by 95 percent.

Step closer to digital babies. ABN

Washington Moves On to Plan B

Here’s what everyone needs to understand about Ukraine:

The United States has already moved on to Plan B. No, the Biden administration has not issued an official statement on the matter, but the shift has already begun. The Washington Brain-trust has abandoned any hope of winning the war outright (Plan A) and has, thus, adopted a different strategy altogether. (Plan B)

Plan B is a combination of two main elements:

  • A—A Strategy of Denial, which is ‘a defensive approach designed to stop an adversary’ from achieving its goals. In this case, the objective is to prolong the conflict for as long as possible to prevent Russian from achieving a clear victory. That is the top priority.
  • B—To continue to increase and intensify asymmetrical attacks on vital infrastructure and civilian areas in Russia proper in order to inflict as much damage on Russia as possible.

This, in essence, is Plan B. Any concern for the Ukrainian people or the future viability of the Ukrainian state, have not been factored in to Washington’s cynical calculation. What matters is preventing a Russian victory and inflicting as much pain on Russia as possible. Those are the primary objectives. In practical terms, that means that more Ukrainian soldiers will be slaughtered wholesale in order to continue using Ukraine as a launching pad for attacks on Russia. 

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This essay by Mike Whitney makes some good points but he misses the real goals of the West. They are: 1) destroy Ukraine. Empty it of its citizens by killing its military-aged men and forcing the rest to flee. 2) Then, destroy the Russian state, dismember it, and seize its assets. Russia is geographically huge with enormous resources, yet its population is a mere 140 million. The ultimate goal is take all of it. The Western cabal/ comitatus is manifestly either reckless or confident. My guess is they are confident because they possess a super-weapon, one stronger and more powerful than nukes or entire armies. It’s possible this is it. Maybe it’s not that but something else. War has always been the underlying reality of civilizations and these wars are our reality. ABN

Patrilineal segmentary systems provide a peaceful explanation for the post-Neolithic Y-chromosome bottleneck

Abstract

Studies have found a pronounced decline in male effective population sizes worldwide around 3000–5000 years ago. This bottleneck was not observed for female effective population sizes, which continued to increase over time. Until now, this remarkable genetic pattern was interpreted as the result of an ancient structuring of human populations into patrilineal groups (gathering closely related males) violently competing with each other. In this scenario, violence is responsible for the repeated extinctions of patrilineal groups, leading to a significant reduction in male effective population size. Here, we propose an alternative hypothesis by modelling a segmentary patrilineal system based on anthropological literature. We show that variance in reproductive success between patrilineal groups, combined with lineal fission (i.e., the splitting of a group into two new groups of patrilineally related individuals), can lead to a substantial reduction in the male effective population size without resorting to the violence hypothesis. Thus, a peaceful explanation involving ancient changes in social structures, linked to global changes in subsistence systems, may be sufficient to explain the reported decline in Y-chromosome diversity.

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Generative AI could soon decimate the call center industry, says CEO

A HOT POTATO: It’s no secret that certain types of jobs are more threatened by artificial intelligence than others. Call center workers fall into this category, and while we’ve already seen a few companies replace phone-based support staff with generative AI, there are warnings that the entire industry could be comprised mostly of chatbots in as soon as a year.

The grim prediction comes from K Krithivasan, head of Indian IT giant Tata Consultancy Services (TCS). The second-largest company in India by market cap, it has more than 616,000 employees worldwide.

Speaking to the Financial Times, Krithivasan said AI will result in a “minimal” need for call centers. The CEO added that while “we have not seen any job reduction” so far, that will change as multinational clients adopt generative AI. The technology is expected to have a massive impact on the customer help center industry, which, according to a Gartner report in 2022, employs about 17 million people.

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Look Who Is Attending the Lawfare Trial in New York City

…For those who do not know, the guy circled coming out of the courtroom is Norm Eisen, one of the primary architects of the Lawfare attack scheme.  Eisen, Mary McCord and Andrew Weissmann construct the motions, briefings and legal strategies for the various state and federal prosecutions in DC, New York and Georgia.

Remember these specific names:  Mary McCord, Norman Eisen and Andrew Weissmann.  You will see them repeated in a pattern throughout the Trump attacks.  Weissmann, Eisen and McCord have been enmeshed since 2016 and the original DOJ/FBI targeting effort against Donald Trump on behalf of Hillary Clinton.

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‘Explain To Me Why We Don’t Have The Right To Exist?’ — Eva Vlaardingerbroek Warns Whites Against Massive Demographic Changes In Their Native Countries

In an exclusive interview with Remix News, Dutch political commentator and lawyer Eva Vlaardingerbroek warns Europeans that they must take a stand against rapid demographic change or become a minority in their native countries.

You’ve spoken a lot about White rights and the White replacement. But of course this kind of opens you up to these accusations of racism. So, how do conservatives deal with this Catch-22 of not wanting to be replaced in their native countries, but also not wanting to be attacked with this term?

You can’t. That’s the thing, you can’t. So you have to pick a side. Of course, you’re going to be attacked if you say, “Hey, this continent, Europe, has been predominantly White for the entirety of its history, and now suddenly within one generation, a few bureaucrats have decided against the will of the people that we should suddenly be a minority. Why do we agree with that, or why do we allow that to happen?” If you say that, you are going to be attacked.

But the only other option then you have is saying nothing and have it happen, so the choice is yours, and I’ve made my choice. I think there are many ways in which you can defend yourself, of course, against this ridiculous attack, so I’m sure that they’re going say about me that I’m a terrible racist again. No, that’s not true. I don’t think that any race is superior to another. I just think that mine is also not inferior to that of others.

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THE REBIRTH OF SLAVERY IN UKRAINE: ZELENSKY’S POLITICAL PROXIES KIDNAP AND SELL PEOPLE, MAKING MONEY FROM THE SLAVE TRADE

The victims of the slave trade, which is overseen by the Ukrainian government, are most often the most socially vulnerable categories of citizens, such as single childless men and single women with children. These people are often in dire financial straits and are looking for work to support themselves and their families. The perpetrators exploit these factors by searching for potential victims on social media or attracting them by posting high-paying job offers on spicialised websites.

Participants in the criminal scheme then conduct interviews with their potential victims, where they screen out unsuitable people who have close relatives or family. The same scheme is then followed: victims are invited to work at remote sites where they are promised stable and high earnings. However, upon arrival at the site, their documents are taken away and they are placed in prison-type premises where they are completely isolated from the outside world. Victims who fall for the tricks of criminals are not allowed to use the telephone or other means of communication.

The average time between entering the slave “prison” and subsequent sale is from 3 to 6 weeks, during which “Ukrainian slaves” are forced to work on farms for 12-14 hours a day, without days off, proper food and rest, regardless of sex and age. It is reported that centers for future slaves are deliberately built near fields and farmland, and people are lured by high-paying and “low-stress work in the fresh air”. Members of disadvantaged families, single mothers and the homeless agree to attractive conditions, but once in the “prison,” they are forced to do hard physical labor until they are sold into slavery at home or abroad. Invigilators use physical and psychological violence to force victims to work and obey. In some cases, they are sexually abused and subjected to other forms of exploitation.

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Finnish researchers: Soil microbes could be added to dietary recommendations

Finnish dietary recommendations do not include advice on soil microbe diversity, which has considerable health benefits and is currently missing from the digestive systems of many people in Finland.

This could be one factor behind many modern health problems, researchers suggest, and changing the recommendations could have positive impacts.

…The research review found that families where even one person does gardening work have much greater diversity of microbes in their guts.

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Tibetan Buddhist viharas were the model for European colleges and Islamic madrasas

Central Asian scholars also developed an Islamic system of higher education modeled on the Central Asian system of the Buddhist vihâra, or monastic college. The vihâra was supported by a tax-exempt pious foundation that paid the expenses of the students and also of the teacher or teachers, who lived in the vihâra with the students. The primary method of teaching was oral lecture and debate, and the main subject of study was the Dharma, or Buddhist law and theology. These fundamental elements were taken over wholesale by the Arabs, who adopted even the distinctively Central Asian form of the vihâra architectural plan—a square structure with a large courtyard, each side of which contained chambers for the students and teachers plus four îwâns, large half-open halls in the form of gateways. The vihâra seems to have been Islamicized as the madrasa in Central Asia in the eighth and ninth centuries, though it is only noted in historical sources somewhat later.

Beckwith, Christopher I.. Empires of the Silk Road: A History of Central Eurasia from the Bronze Age to the Present (p. 154). Princeton University Press. Kindle Edition.

Medieval Western European culture grew intellectually as a direct result of contact with Muslim Spain and Palestine. The translation into Latin of Arabic books introduced new, exciting, and often controversial ideas. The work of al-Khwârizmî54 (Algorithmus) translated as the Book of Algorithmus introduced Arabic numerals, including the zero and “algorithmic” calculation along with them, while the Algebra introduced advanced algebraic mathematics. They were revolutionary to the scientifically oriented minds of Western Europe. The translation of previously unknown philosophical and logical works of Aristotle, along with the works of the great Islamic Aristotelian philosophers, also caused fundamental restructuring of Western European thought. The ideas accompanied at least one important institution. The first European college,55 the Collège des Dix-huit or ‘College of the Eighteen Scholars’, was established in Paris in 1180 by Jocius of London (Jocius de Londiniis) after his return from the Holy Land.56 It was the oldest of the colleges that formed the original University of Paris. The college retained most of the essential characteristics of its direct ancestors, the madrasa and vihâra, including the pious foundation that supported the student residents and a professor,57 and perhaps the architectural form as well.58 The transmission of Islamic knowledge, techniques, and institutions to the West thus fueled the intellectual revolution of the High Middle Ages.

Beckwith, Christopher I.. Empires of the Silk Road: A History of Central Eurasia from the Bronze Age to the Present (pp. 179-180). Princeton University Press. Kindle Edition.

Harvey Weinstein Conviction Overturned On Appeal

A New York Court of Appeals has overturned Harvey Weinstein’s 2020 conviction on felony sex crime charges, for which he was sentenced to 23 years in prison.

In a 4-3 decision, the court found that the trial judge in the disgraced mogul’s case had made a critical error, allowing prosecutors to call a series of women as witnesses who said that Weinstein had assaulted them, but whose accusations weren’t part of the charges against him, the NYT reports.

In 2020, Lauren Young and two other women, Dawn Dunning and Tarale Wulff, testified about their encounters with Weinstein under a state law that allows testimony about “prior bad acts” to demonstrate a pattern of behavior. But the court in its decision on Thursday said that “under our system of justice, the accused has a right to be held to account only for the crime charged.”

…Citing that decision and others it identified as errors, the appeals court determined that Mr. Weinstein, who as a movie producer had been one of the most powerful men in Hollywood, had not received a fair trial. The four judges in the majority wrote that Mr. Weinstein was not tried solely on the crimes he was charged with, but instead for much of his past behavior. -NYT

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