Summary
The production methods of Pfizer and Moderna’s COVID-19 vaccines have been thrown into the spotlight due to the discovery of DNA contaminants in the vaccine vials by genomic scientist Kevin McKernan. The DNA found was not only considerable in quantity but also protected by the lipid nanoparticles used for mRNA delivery, implying potential delivery into human cells.
Additionally, a promoter from the SV40 virus, undisclosed in initial vaccine data, was found within the DNA. The presence of this promoter has raised serious questions about the oversight and regulatory processes in vaccine manufacturing. Despite the speed and economic advantages associated with mRNA vaccine technology, concerns around DNA contamination underline the importance of rigorous safety checks.
Introduction
This report aims to shed light on the actual implications of McKernan’s findings of DNA contaminants in the vaccines, exploring the nature and potential impact of the DNA contaminants in the vaccines. It also delves into concerns over the lax regulatory oversight and the potential risks posed by DNA contamination for future RNA vaccines.
Background
Synthetic mRNA forms the backbone of Pfizer and Moderna’s COVID-19 vaccines. The mRNA was produced in a cell free environment in a laboratory where a DNA template was used with a cocktail of enzymes and nucleic acid building blocks to produce the mRNA. The DNA template was originally created in bacteria.
As well as a nucleus, bacteria have circular strands of DNA, called plasmids, in their cytoplasm. It is relatively easy to introduce DNA into the cytoplasm of bacteria. The bacteria use the DNA to make mRNA and then use that to make protein. Bacteria regularly exchange these plasmids, or parts of them and that is often how bacteria become antibiotic resistant. Researchers hijack this system to use bacteria to make what they need.
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McKernan himself says this article ‘gets it right.’ ABN