A specialized network responsible for washing away cellular waste in the brain might play a role in the development of schizophrenia and other psychotic disorders. In a recent brain imaging study, researchers found that young people at a high genetic risk for psychosis showed early signs of a malfunctioning brain clearance system, which was linked to a toxic buildup of stimulating chemicals. The research was published in the journal Biological Psychiatry Global Open Science.
Every day, the brain generates metabolic waste as it processes information. To keep the biological environment stable, a network called the glymphatic system flushes out this debris. This system pushes cerebrospinal fluid into the brain tissue, where it mixes with the fluid surrounding the cells. The fluid then washes away extra neurotransmitters, inflammatory proteins, and misfolded proteins.
This fluid movement is driven by star-shaped brain cells called astrocytes. Astrocytes have specialized water channels, called aquaporin-4 channels, that act like tiny valves. When these channels fail to work properly, or when the blood vessels leak, the entire clearance process slows down. Waste products then accumulate in the brain tissue, potentially causing damage.
A faulty brain waste disposal system may lead to psychosis
American Buddhist Net 