Until the concept of reuptake inhibition is recognized fundamentally as propaganda instead of science, no one is going to understand why these drugs cause birth defects and alterations to fetal brain development or why they stop you from being able to feel your genitals and nipples or why tapering from long-term use causes catastrophic new-onset syndromes that have little to do with why anyone took them in the first place.
Serotonin was first named “enteramine” in 1935 meaning “an amino acid derivative present in the gut.”
It was named “serotonin” in 1948, meaning “substance in the blood (sero- for serum) that increases vasoconstriction (-tonin for vascular tone).
In 1952, it was established that entermaine and serotonin were the same compound.
Had serotonin research not been completely perverted by Pharma, it would have become rapidly apparent that these are deeply connected: serotonin’s one role in the entire body is to coordinate mitochondrial function in response to variation in the supply and demand of oxygen. It regulates motility in the gut to prevent local hypoxia. It coordinates blood flow to maximize efficiency of oxygen delivery.
But when SSRIs were released in 1986, Pharma solidified the destruction of these lines of inquiry by selecting a thread started by the influence of LSD in the 1950s that claimed serotonin was a lever to be pulled to manipulate the state of the brain.
The “R” in SSRIs is an insidious lie.
It implies that SSRIs specifically inhibit “reuptake” of serotonin, a phenomenon only relevant to the first neuron of a synapse.
This created the total mythology that the one thing they do is keep serotonin in the synapse longer to have greater activity on the receiving neuron.
They knew this was false.
They knew these are generic inhibitors of the serotonin transporter, which is not primarily found in the brain and is not primarily found in neurons.
Its has tremendous expression in the gut, lungs, and reproductive organs.
It’s found inside cells, most likely mediating the established direct transport of serotonin into mitochondria.
On a cellular basis the highest expression is in enterocytes, not in enteric neurons, and in the placenta.
The word “SSRI” is pure propaganda meant to cut out almost all of the relevant serotonin research in the way that Stalin cut out Trotsky from all the pictures of the two of them with Lenin to paint himself as Lenin’s true successor.
They are “serotonin transporter inhibitors.”
Until the concept of reuptake inhibition is recognized fundamentally as propaganda instead of science, no one is going to understand why these drugs cause birth defects and alterations to fetal brain development or why they stop you from being able to feel your genitals and nipples or why tapering from long-term use causes catastrophic new-onset syndromes that have little to do with why anyone took them in the first place.