This is a short and informative read on why soap works so well in preventing viral transmission. Soap is better than alcohol and disinfectant wipes.
Evolution can favor mild viral infections, thus possibly making East Asians more susceptible to Covid19
…I [have] argued that coronaviruses have coevolved with the Chinese population, to the point of developing a commensal relationship. A few points:
– Such viruses include the common cold and are normally mild in their effects.
– Repeated coronaviral infections of lung tissue may actually help increase resistance to more serious pulmonary infections, like tuberculosis, pneumonia, and the Spanish flu of 1918—which curiously spared China.
– Chinese lung tissue would thus facilitate coronaviral infections as a sort of routine vaccination.
– If this is true, modern medicine has inadvertently made the Chinese population particularly vulnerable to deadly diseases like the Wuhan coronavirus by reducing the prevalence of milder pulmonary infections. (Coevolution with the plague)
This is the best essay I have seen on the topic of are or why are East Asians more susceptible to Covid19.
Nowadays, the topic of racial differences is avoided like the plague. If Covid19 is more harmful to East Asians (Mongoloids) due to ACE2 receptor differences in the lungs, no one benefits from hiding that information.
Good overview of Game Theory as applied to Artificial Intelligence
Game theory is experiencing a renaissance driven by the evolution of AI. What are some classic and new ideas that data scientists should be aware of.
Game theory is one of the most fascinating areas of mathematics that have influenced diverse fields such as economics, social sciences, biology and, obviously, computer science. There are many ways to think about game theory but one that I find really helpful, although overly simplistic, is:
game theory is probabilities with incentives
Games are playing a key role in the evolution of artificial intelligence(AI). For starters, game environments are becoming a popular training mechanism in areas such as reinforcement learning or imitation learning. In theory, any multi-agent AI system can be subjected to gamified interactions between its participants. The branch of mathematics that formulates the principles of games is known as game theory. In the context of artificial intelligence(AI) and deep learning systems, game theory is essential to enable some of the key capabilities required in multi-agent environments in which different AI programs need to interact or compete in order to accomplish a goal. (A Crash Course in Game Theory for Machine Learning: Classic and New Ideas)
Humidity is a major protectant from COVID-19. Both by reducing infection and reducing severity of symptoms.
[I found the below text among comments on this page. There is no direct link to the comment itself. There are many supporting sources and the information sounds right. Additionally, no harm will come from upping indoor humidity. ABN]
Extremely important right now: Humidity is a major protectant from COVID-19. Both by reducing infection and reducing severity of symptoms.
I am a researcher who just wrote a paper on the subject. Please help me get the word out. This is not hype. Read all the papers on the subject.
If there is a pandemic in America, it could be Trump’s Waterloo.
Sincerely,
Daniel Hess
See below:
——————–
Defending Against COVID-19 Through Indoor Humidification
Daniel A. Hess
Virology Researcher, Rockville, MD
February 26, 2020
Overview
There is ample research showing that viral outbreaks similar to COVID-19 are strongly correlated with humidity levels. Cold and flu generally peak during the winter months in temperate zones, when indoor humidity is low. Notably, influenza and cold viruses tend to survive far longer in the air when the ambient humidity is low than when the ambient humidity is high. Further, there is strong evidence that the severity of respiratory infection is similarly humidity dependent, as lower humidity leads to more severe flu illness and greater likelihood of death. Influenza and COVID-19 are very similar in that death typically results from pneumonia that leads to acute respiratory failure.
Thus, indoor humidification, particularly to 50% relative humidity or higher, is seen as a strong partial defense against COVID-19, by two different mechanisms. First, by reducing the amount of time that virus particles remain infectious in the air, humidification is expected to substantially reduce R0, the reproductive number that represents outbreak contagiousness. Second, by reducing severity of respiratory infection, mortality rates from COVID-19, currently estimated at 2.3%, may be substantially reduced.
Indoor humidification is readily available almost everywhere and can be achieved by common humidifiers and even by boiling water in impoverished areas where humidifiers are not available. Available research strongly suggests that humidification in homes, hospitals, schools and other public areas will dramatically reduce both COVID-19 transmission and COVID-19 mortality among those who become infected. Even in areas where medical infrastructure becomes overwhelmed during pandemic conditions, indoor humidification will remain widely available as a defense against COVID-19 infection and severity.
Evidence so far is strong that COVID-19 exhibits climate and seasonal characteristics similar to influenzas and the common cold. By mimicking the environmental conditions of the summer months through indoor humidification, it is believed that COVID-19 incidence and severity will be sharply reduced.
Indoor humidification, especially to 50% relative humidity or higher, is likely to emerge as a robust tool that will be widely adopted as a defense against COVID-19.
I. Virus particles remain active longer in dry air than in humid air: citations
1. Noti et al. (2013) High Humidity Leads to Loss of Infectious Influenza Virus from Simulated Coughs. PLoS One. 2013; 8(2): e57485.
2. Tamerius JD, et al. (2013) Environmental predictors of seasonal influenza epidemics across temperate and tropical climates. PLoS Pathog 9:e1003194, and erratum 2013 Nov;9(11).
3. Shaman J, Pitzer VE, Viboud C, Grenfell BT, Lipsitch M (2010) Absolute humidity and the seasonal onset of influenza in the continental United States. PLoS Biol 8(2): e1000316.
4. Shaman J, Goldstein E, Lipsitch M (2011) Absolute humidity and pandemic versus epidemic influenza. Am J Epidemiol 173: 127–135
5. Lowen AC, Mubareka S, Steel J, Palese P (2007) Influenza virus transmission is dependent on relative humidity and temperature. PLoS Pathog 3(10): 1470–1476.
6. Schaffer FL, Soergel ME, Straube DC (1976) Survival of airborne influenza virus: effects of propagating host, relative humidity, and composition of spray fluids, Arch Virol. 51: 263–273.
7. Hanley BP, Borup B (2010) Aerosol influenza transmission risk contours: A study of humid tropics versus winter temperate zone. Virol J 7: 98.
8. Yang W, Marr LC (2011) Dynamics of airborne influenza A viruses indoors and dependence on humidity. PloS One 6(6): e21481.
9. Shaman and Kohn (2009) Absolute humidity modulates influenza survival, transmission, and seasonality. PNAS March 3, 2009 106 (9) 3243-3248
II. Susceptibility to respiratory infection is greater when ambient humidity is low than when ambient humidity is high: citations
1. Kudo et al. Low ambient humidity impairs barrier function and innate resistance against influenza infection. Proceedings of the National Academy of Sciences, 2019.
2. Makinen et al. Cold temperature and low humidity are associated with increased occurrence of respiratory tract infections. Respiratory Medicine, Volume 103, Issue 3, March 2009, Pages 456-462
3. Eccles R (2002) An explanation for the seasonality of acute upper respiratory tract viral infections. Acta Otolaryngol 122:183–191.
4. Iwasaki A, Pillai PS (2014) Innate immunity to influenza virus infection. Nat Rev Immunol 14:315–328.
5. Chen X, et al. (2018) Host immune response to influenza a virus infection. Front Immunol 9:320.
6. Taubenberger JK, Morens DM (2008) The pathology of influenza virus infections. Annu Rev Pathol 3:499–522.
7. Bustamante-Marin XM, Ostrowski LE (2017) Cilia and mucociliary clearance. Cold Spring Harb Perspect Biol 9:a028241.
8. Oozawa H, et al. (2012) Effect of prehydration on nasal mucociliary clearance in low relative humidity. Auris Nasus Larynx 39:48–52.
9. Kudo E, et al. (2019) Low ambient humidity impairs barrier function, innate resistance against influenza infection. NCBI BioProject. Available at https://www.ncbi.nlm.nih.gov/ bioproject/PRJNA528197. Deposited March 20, 2019.
III. Applicability to COVID-19
The emergence of COVID-19 during winter in temperate zones strongly suggests that COVID-19 is similar to flu and cold viruses in its correlation with ambient humidity levels.
COVID-19 outbreaks to date have overwhelmingly been in temperate zones where indoor humidity in winter is low. To date, major outbreaks have occurred in China, Korea, Japan, Italy and Iran. Each of these outbreaks occurred in a temperate country in the midst of winter, where indoor humidity would be expected to be quite low. There are few cases and no known major outbreaks of COVID-19 in tropical and subtropical regions. Notably South America, Africa, and the Indian subcontinent have few reported cases and (as far as the author is aware) no known cases of local transmission, suggesting that the warm and humid conditions in those regions hinders COVID-19.
Singapore, notably, had what appeared to be the beginning of a major outbreak of COVID-19 around February 14, 2020. Instead the incidence of new COVID-19 infection in Singapore has since diminished dramatically and there have been no COVID-19 fatalities in that country. Most patients in Singapore who tested positive for COVID-19 have already recovered, as of this writing. This favorable outcome strongly suggests to the author that the warm and humid climate of Singapore has been protective against COVID-19 transmission and severity.
The environmental conditions of Singapore could be substantially replicated through indoor humidification, especially to 50% relative humidity or higher, and in this way major reductions in COVID-19 transmission and severity can be achieved in other countries.
IV. Preparing for Seasonal Re-Emergence
As noted, evidence available so far strongly suggests that COVID-19 contagiousness and severity are strongly dependent on ambient humidity levels, and thus COVID-19 occurrence is expected to diminish during the summer months.
However, re-emergence of COVID-19 during the winter of 2020-2021 is likely as indoor humidity levels in the Northern Hemisphere again drop. The author hopes that a COVID-19 vaccine will be available and in wide distribution by that time. This may require a reduction in the regulatory hurdles that slow the development of vaccines in the United States and elsewhere.
Are 1,200 bodies burned every day in mobile incinerators in Wuhan?
This information is has not been confirmed but it comes from a famous Chinese dissident who also happens to be a billionaire. I do not believe he is lying. His information may be wrong, but many other signs point to a large pandemic that can no longer be contained. Watch the vid and decide for yourself.
EDIT: Here is another tape from Guo.
What we know about COVID-19 and some speculation
First, what we know:
Speculation based on what I have read, COVID-19:
- is likely a bio-weapon that escaped from a BSL-4 (Biosafety level 4) laboratory in Wuhan, China
- it could also be a dangerous naturally-occurring virus being studied at that lab
- statistics on numbers of infected and deaths in China are grossly underreported
- clusters appearing in other parts of the world and within institutions indicate significant likelihood that a worldwide pandemic may be unavoidable
- the virus attacks through ACE 2 receptors in the lungs
- at this point in time, this seems to indicate that Mongoloid-type individuals (who have more ACE 2 receptors than others) are more susceptible to the virus, though this has not been confirmed. Counterevidence includes: a) China is the epicenter and b) disease clusters are also appearing in Italy and Iran
- the WHO has been very ineffective against COVD-19 and may have hindered early containment (due to political connections with China’s CCP)
- the virus is highly contagious and can be spread by carriers who are entirely symptomless
- thus, it is only reasonable to take extra precautions against transmission: clean hands, don’t touch your face, shower more often, avoid crowds, and keep your distance from others
As for whether COVID-19 is a bio-weapon, DNA analyses seem to show that it is an unusually contagious chimera that could not have occurred naturally. WHO and all governments have been downplaying the danger of the virus to avoid panic and/or angering China.
If the virus is eventually shown to be a bio-weapon, worldwide turmoil will ensue. The above is what I have gathered from reading about the virus. On a small site like this, we can be honest without worrying about contributing to worldwide panic.
My listing of probabilities and uncertain evidence above is a sort of Bayesian reasoning tree. If any of the parts change, the whole tree could also change. A few other pieces of evidence in this line of reasoning are: a) a bio-weapon pandemic has been predicted for decades, largely because bio-weapons exist and several have already escaped (Lyme, SARS, MERS, etc); and b) a simulation of just such a pandemic was conducted in October 2019.
EDIT: Twitter feed with frequent updates: #Covid19
