An interesting Swedish study (described here: Creativity ‘closely entwined with mental illness’) found not that creative people have higher incidences of mental illness, but rather that they are more likely to be related to someone with mental illness.
As a Buddhist, I am inclined to think most people are deluded, crazy if you will. From my practice of FIML, I am certain that most people suffer significant interpersonal stress due to ambiguities in language/communication that are rarely if ever dealt with in a satisfactory manner.