See image below for a clear visualization of the difference between absolute and relative risk reduction. Absolute risk reduction generally provides the best information for making informed health decisions.
Relative risk reduction and absolute risk reduction measures in the evaluation of clinical trial data are poorly understood by health professionals and the public. The absence of reported absolute risk reduction in COVID-19 vaccine clinical trials can lead to outcome reporting bias that affects the interpretation of vaccine efficacy. The present article uses clinical epidemiologic tools to critically appraise reports of efficacy in Pfzier/BioNTech and Moderna COVID-19 mRNA vaccine clinical trials.Outcome Reporting Bias in COVID-19 mRNA Vaccine Clinical Trials