Studies support the successful use of PVP-I (0.5% – 1.0% solution) to prevent and/or treat COVID-19. The best results were obtained by applying PVP-I to the nasal cavity, nasopharynx, oral cavity, and oropharynx, every 4 hours. The methods were nasal irrigation, mouth rinsing, and gargling. Some may also be applied in spray form. Saline solution is preferable for nasal use.
PVP-I works by inactivating the virus on the mucosal surfaces of the mouth, nasal cavity, and throat. It destroys coronavirus’ envelope and/or membrane. PVP-I inactivates the virus present at the time of application. It also remains on the mucosal surfaces for some time and continues to destroy virus that appears on them from outside and inside.link