The ADJUVANT EFFECT explains why the immune system declines in fully vaccinated, a phenomenon seen in both Israel and UK and probably elsewhere

It is the adjuvant effect that is protecting vaxxed in the short term and then rapidly falling off, weakening their entire immune system. This is explained in the quote below and further elucidated in the essay from which it comes. That essay discusses Israeli results. This article shows the the fall off of the adjuvant effect in UK. ABN

…the single most important confounder of all Covid-19 vaccine efficacy studies conducted thus far: innate immunity. It is well known that, regardless of any induced antigen (Ag)-specific adaptive immune response, all vaccines (including mRNA vaccines) have an adjuvant effect: they stimulate innate immune effectors, some of which have antiviral activity and/or facilitate adaptive immunity (2, 3, 4). Without going into mechanistic detail, there is no doubt that some of these innate, nonAg-specific immune responses have a short-lived antiviral effect. This could already explain why booster doses in the population described above can prevent viral infection while recalling anti-spike Abs. It may also be tempting to assume that these recalled Abs are now responsible for enhanced protection from both infection and disease. However, from an immunological viewpoint, it is difficult to understand how a rapid recall of the very same anti-S Abs in a previously vaccine-primed population would now all of a sudden enable better protection from infection and disease. If innate immunity is indeed the confounder, then the outcome of long-term surveillance studies would look very different. Given the more potent neutralizing Abs booster shots are generating against variants (5), the S(pike)-directed immune pressure in the population will only continue to rise while still failing to curtail the spread of the predominantly circulating highly infectious SARS-CoV-2 variant (e.g., Delta variant). On the contrary, it would be reasonable to assume that upon an additional booster shot the more potent Abs further contribute to selecting S-directed immune escape variants and, therefore, turn the previously primed population in an even more fertile breeding ground for the highly infectious Delta variant.

link

Leave a Reply

Please log in using one of these methods to post your comment:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out /  Change )

Google photo

You are commenting using your Google account. Log Out /  Change )

Twitter picture

You are commenting using your Twitter account. Log Out /  Change )

Facebook photo

You are commenting using your Facebook account. Log Out /  Change )

Connecting to %s