So this analysis now becomes … not just very important, but pivotal…
Omicron bore a modification to this peptide to make it weaker… remember, Omicron’s genetics are older than the stronger forms of SARS-CoV-2…
A form with a proline change (Omicron) was used to create immunity, then the stronger form hit those nations without immunity hard.
"The binding epitope on [SARS-CoV-2] S [Spike Protein] harbors a sequence motif unique to SARS-CoV-2 (not present in other SARS-related coronaviruses), which is highly similar in both sequence and structure to the bacterial superantigen staphylococcal enterotoxin B."
Of the many mutations in omicron the most interesting two are in the SEB domain.
Staphylococcus Enterotoxin B is a peptide that is classified as a bioweapon.
When ingested it creates symptoms very similar to COVID and it’s know to trigger cytokine storms
It’s well described in Cheng et al.
This known toxin was warp sped into spike only Vaccines.
SEB is directly adjacent to the FCS.
Let’s have a look at what Ahanotu et al has to say about SEB exposure and it’s capacity as a bioweapon.
https://www.pnas.org/content/117/41/25254
Exposure to these peptides has been known to cause cytokine storms.
They are superantigens.
https://www.liebertpub.com/doi/pdfplus/10.1177/153567600601100303
Now look at Omicron spike protein 671-692.
Two amino acid changes and one is the infamous proline change near the FCS. Prolines are right angle brackets in proteins. When they change, they alter structure.
P681H
N679K
This may attenuate the SEB toxicity. Fewer Ckine storms.
Ahanotu et al considerations on SEB as a bioweapon as prescient.
Some of this is discussed in our preprint.
I was not aware of these SEB mutations in omicron when I wrote this.
I was C19 +ve when I submitted this, ironically.
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Originally tweeted by Kevin McKernan 🙂 (@Kevin_McKernan) on December 11, 2021.
"These data suggest that SARS-CoV-2 S may act as a superantigen to trigger the development of MIS-C as well as cytokine storm in adult COVID-19 patients."
Originally tweeted by Ethical Skeptic ☀ (@EthicalSkeptic) on December 11, 2021.
Originally tweeted by Ethical Skeptic ☀ (@EthicalSkeptic) on December 11, 2021.
Originally tweeted by Ethical Skeptic ☀ (@EthicalSkeptic) on December 11, 2021.
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