Ayahuasca’s psychedelic impact revealed in brain scans

The results, published in the journal Proceedings of the National Academy of Sciences, provide the most advanced picture yet of the human brain on psychedelics. The recordings show how the brain’s normal hierarchical organisation breaks down, electrical activity becomes anarchic, and connectivity between regions soars, particularly those handling “higher level” functions such as imagination, which evolved most recently in humans. “The stronger the intensity of the experience, the more hyperconnected were those brain areas,” said Timmermann.

“At the dose we use, it is incredibly potent,” said Robin Carhart-Harris, a professor of neurology and psychiatry at the University of California, San Francisco. “People describe leaving this world and breaking through into another that is incredibly immersive and richly complex, sometimes being populated by other beings that they feel might hold special power over them, like gods.”

He added: “What we have seen is that DMT breaks down the basic networks of the brain, causing them to become less distinct from each other. We also see the major rhythms of the brain – that serve a largely inhibitory, constraining function – break down, and in concert, brain activity becomes more entropic or information-rich.”

link