In gout, reduction of Serum Uric Acid (SUA) to normal levels results in disappearance of urate crystals from synovial fluid (SF), requiring a longer time in those patients with gout of longer duration. This indicates that urate crystal deposition in joints is reversible. Normalization of SUA levels results in a decrease in the concentration of monosodium urate (MSU) crystals in SF in the asymptomatic gouty joints. This may partially explain the reduced frequency of gouty attacks when a patient has been treated with SUA‐lowering drugs.
The time required for disappearance ranged from 3 to 33 months; disappearance time correlated with the duration of gout.
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Time required for disappearance of urate crystals from synovial fluid after successful hypouricaemic treatment relates to the duration of gout
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