A new model of the brain is emerging from research that shows that:
The brain is highly dynamic, reorganizing its activity at different interacting spatial and temporal scales, including variation within and between brain networks. (The spatial chronnectome reveals a dynamic interplay between functional segregation and integration)
Traditionally, models of brain activity have assumed networks were spatially more fixed. More information about this study can be found here: Structure of Brain Networks Is Not Fixed, Study Finds.
In Buddhist literature, it is frequently stated that one’s karma can be completely changed in the “duration of a single thought,” or words to that effect.
If we understand karma to mean the work or ongoing functional habits of the mind, and consider that in light of the above findings, we may fairly conclude that thousands of years of Buddhist practice have been based on valid insights into how our brains actually operate.
Buddhist concepts of non-attachment, emptiness, and impermanence can also be seen in this light. And this would apply both to individual psychology, group psychologies, or the cosmos itself from a Mind Only perspective.
A good tool to have is the understanding that even deep psychological states can be transformed in a moment’s time. Consider also that the Buddha did describe some individual traits as “persistent” or unchanging even after enlightenment.