LSD alters dynamic integration and segregation in the human brain

…Our main finding is that the effects of LSD on brain function and subjective experience are non-uniform in time: LSD makes globally segregated sub-states of dynamic functional connectivity more complex, and weakens the relationship between functional and anatomical connectivity. On a regional level, LSD reduces functional connectivity of the anterior medial prefrontal cortex, specifically during states of high segregation. Time-specific effects were correlated with different aspects of subjective experiences; in particular, ego dissolution was predicted by increased small-world organisation during a state of high global integration. These results reveal a more nuanced, temporally-specific picture of altered brain connectivity and complexity under psychedelics than has previously been reported.

LSD alters dynamic integration and segregation in the human brain

A good article explaining the study can be found here: Neuroscience study indicates that LSD “frees” brain activity from anatomical constraints.

“Studying psychoactive substances offers a unique opportunity for neuroscience: we can study their effects in terms of brain chemistry, but also at the level of brain function and subjective experience,” he added. “In particular, the mind is never static, and neither is the brain: we are increasingly discovering that when it comes to brain function and its evolution over time, the journey matters just as much as the destination.”

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