“The mass vaccination program has driven natural selection and adaptation of more infectious SARS-CoV-2 (SC-2) variants that have now evolved to causing enhanced susceptibility of vaccinees to infection (due to antibody-dependent enhancement of infection; ADEI). The resulting recurrence of infectious episodes leads to hyperactivation of cytotoxic CD8+ T cells that are directed at a universal (i.e., MHC-unrestricted) T cell epitope comprised within the SC-2 spike (S) protein. As these cytotoxic CD8+ T cells enable prompt abrogation of productive infection and as this epitope is shared amongst some other glycosylated viruses causing acute self-limiting infection or disease, more and more cases of asymptomatic infections are to be expected in vaccinees, especially in those endowed with a mature and fully functional innate immune system.”
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