Tag: brain science

How the brain processes new information

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A new paper provides fascinating insight into how our brains amass information and organize and assess it in real-time.

The paper—Cliques of Neurons Bound into Cavities Provide a Missing Link between Structure and Function—proposes that “the brain processes stimuli by forming increasingly complex functional cliques and cavities.”

The full intro to the paper:

The lack of a formal link between neural network structure and its emergent function has hampered our understanding of how the brain processes information. We have now come closer to describing such a link by taking the direction of synaptic transmission into account, constructing graphs of a network that reflect the direction of information flow, and analyzing these directed graphs using algebraic topology. Applying this approach to a local network of neurons in the neocortex revealed a remarkably intricate and previously unseen topology of synaptic connectivity. The synaptic network contains an abundance of cliques of neurons bound into cavities that guide the emergence of correlated activity. In response to stimuli, correlated activity binds synaptically connected neurons into functional cliques and cavities that evolve in a stereotypical sequence toward peak complexity. We propose that the brain processes stimuli by forming increasingly complex functional cliques and cavities.

The cliques of neurons that grow and connect in real-time make up the transient “architecture” of awareness as it changes and responds to stimuli.

You can observe a process that seems to fit this description by simply turning your head and looking around. As your eye settles on something to consider in more detail, neuronic cliques will grow in your brain based on that stimulus.

Depending on the significance to you of what you are looking at, further associations drawn from memory and emotion will aggregate around it.

Interestingly, the concept of transient neuronal cliques that grow into larger structures fits very well with the Buddha’s Five Skandhas explanation of the path between perception and consciousness.

This paper also seems to explain why FIML practice works. FIML interrupts the (re)formation of mistaken neuronal cliques in real-time, thus preventing the (re)association of (mistaken) established mental states with new perceptions. If there was no mistake FIML affirms that truth.

By consciously interfering with habitual neuronal cliques, FIML eliminates the false and unwanted psychological structures that give rise to them.

FIML works because large (mistaken) psychological brain structures rely on reconsolidation through the continual processing of “new” information that falsely reconfirms them.

As such, human psychology to a large extent is an ongoing self-fulfilling prophesy.

Here is an article about the paper: Brain Architecture: Scientists Discover 11 Dimensional Structures That Could Help Us Understand How the Brain Works.

The power of words and habit formation

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How we use and hear words becomes a habit.

A recent study on personal space, reported in Personal Space Is a Fear Response, shows that this fear response can be stimulated by words alone.

When placed in an MRI—and told a person was standing over the machine—[people with normal amygdalae] showed heightened activity in their amygdala; when they were told the person was further away from the machine, the activity returned to normal. This shows, says the study’s leader, Ralph Adolphs, that the belief that someone is too close for comfort is enough to spark the same activity as if they actually are.

You could also say that just hearing the words that “someone is too close for comfort is enough to spark the same activity as if they actually are.”

I doubt I need to illustrate this idea as most readers are surely aware that all people have many strong emotional responses to words, gestures, facial expressions, as well as personal space encroachments.

Another recent study, unsurprisingly, shows that forming a habit leaves a lasting mark on specific circuits in the brain. In more detail:

In the basal ganglia, two main types of paths carry opposing messages: One carries a ‘go’ signal which spurs an action, the other a ‘stop’ signal.

Experiments by Duke neurobiology graduate student Justin O’Hare found that the stop and go pathways were both more active in the sugar-habit mice. O’Hare said he didn’t expect to see the stop signal equally ramped up in the habit brains, because it has been traditionally viewed as the factor that helps prevent a behavior.

The team also discovered a change in the timing of activation in the two pathways. In mice that had formed a habit, the go pathway turned on before the stop pathway. In non-habit brains, the stop signal preceded the go.

These changes in the brain circuitry were so long-lasting and obvious that it was possible for the group to predict which mice had formed a habit just by looking at isolated pieces of their brains in a petri dish. (same link as just above)

The study on habits is about mice with sugar habits, but I think it is fair to hypothesize that something similar happens with humans in their use of communication cues.

Humans, in my view, habituate to semiotic stimuli in much the same way that mice habituate to sugar.

The Duke study shows that the stop pathway grew as much as the go pathway in the mice, the main difference being that the go pathway turned on before the stop pathway.

Since human language and its uses is more complex than mice habituated to too much sugar, there must be many more stop and go pathways within the language and communication networks of human beings.

Many of these pathways will be similar among people in the same culture, but many of them won’t. Each human being is a repository of a multitude of idiosyncratic emotional and semantic responses and outputs.

So how do you figure out what your pathways are? And how do you correct ones that aren’t working well? And similarly, how do you figure out your partner’s pathways?

FIML practice helps partners to both identify their idiosyncratic communication habits and correct ones that are not working well. FIML finds and corrects pathways through micro-analysis.

It seems very likely to me that a FIML-style analysis corrects mistaken communication pathways by bringing the stop pathway to the fore. When a particular mistaken response is stopped a few times and under analysis seen to be wrong, the go pathways for that response will tend to be extirpated.

By using words to analyze micro units of miscommunication, FIML partners tap into the power of words to change actual pathways of neurons in their brains, thus reorganizing the deep linguistic basis of habitual psychological responses, no matter how idiosyncratic.

How working memory works and doesn’t work

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A new study on working memory has some intriguing insights into how working memory works and how it doesn’t work.

It’s widely known that when working memory is overtaxed, confusion results, skills decline, while feelings of frustration and anger may arise. The reason for this seems to be:

Feedback (top-down) coupling broke down when the number of objects exceeded cognitive capacity. Thus, impaired behavioral performance coincided with a break-down of Prediction signals. This provides new insights into the neuronal underpinnings of cognitive capacity and how coupling in a distributed working memory network is affected by memory load. (Working Memory Load Modulates Neuronal Coupling)

A well-written article about this study contains the following diagram and explanation:

This article—Overtaxed Working Memory Knocks the Brain Out of Sync—also contains the following passages and quote from one of the study’s authors:

Miller thinks the brain is juggling the items being held in working memory one at a time, in alternation. “That means all the information has to fit into one brain wave,” he said. “When you exceed the capacity of that one brain wave, you’ve reached the limit on working memory.”

…The prefrontal cortex seems to help construct an internal model of the world, sending so-called “top-down,” or feedback, signals that convey this model to lower-level brain areas. Meanwhile, the superficial frontal eye fields and lateral intraparietal area send raw sensory input to the deeper areas in the prefrontal cortex, in the form of bottom-up or feedforward signals. Differences between the top-down model and the bottom-up sensory information allow the brain to figure out what it’s experiencing, and to tweak its internal models accordingly. (Emphasis added)

Working memory works via connections between three brain regions that together form a coherent brain wave.

Notice that “an internal model of the world,” which is a “top-down signal” within the brain wave feedback loop, predicts or interprets “bottom-up” sensory input as it arrives in the brain.

I believe this “top-down signal” within working memory is the reason FIML practice has such enormous psychological value.

By analyzing minute emotional reactions in real-time during normal conversation, FIML practice disrupts the consolidation, or more often the reconsolidation, of “neurotic” responses. (Disruption of neurotic response in FIML practice)

FIML optimizes human psychology by helping partners intervene directly into their working memories to access real-world top-down signals as they are happening in real-time. Doing this repeatedly reliably alters the brain’s repository of top-down interpretations, making them much more accurate and up-to-date.

The model of working memory proposed in this study also explains why FIML can be a bit difficult to do. Partners must learn to allow a FIML meta-perspective or “super top-down” signal to quickly commandeer their working memories so that analysis of whatever just happened can proceed rationally and objectively. It does take some time to learn this skill, but it is no harder than many other “automated” skills such bicycling, typing, or playing a musical instrument.

first posted JUNE 7, 2018

Mindfulness and error recognition

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Mindfulness practices improve our ability to recognize error.

A recent study shows this by monitoring brain activity with an EEG.

The EEG can measure brain activity at the millisecond level, so we got precise measures of neural activity right after mistakes compared to correct responses. A certain neural signal occurs about half a second after an error called the error positivity, which is linked to conscious error recognition. We found that the strength of this signal is increased in the meditators relative to controls,” said Jeff Lin, co-author of the study linked just below. [emphasis mine](link to quote: How meditation can help you make fewer mistakes)

The study is here: On Variation in Mindfulness Training: A Multimodal Study of Brief Open Monitoring Meditation on Error Monitoring.

Few Buddhists will be surprised at the general findings of this study.

Error recognition is what first got me to read about this study.

The findings became even more interesting to me when I saw the statement about the one-half-second error positivity response in the quote above.

Error recognition or the recognition that one might be making an error is key to successful FIML practice.

The second key is to act on our recognition quickly, within a few seconds if possible.

I have always figured it takes about a half second more or less to feel a slight disturbance that tells us we might be forming a wrong impression about what someone is saying or doing. That we might be making an error.

It is this disturbance that tells us it is time to do a FIML query. Virtually every time I do a proper FIML query I find I am either flat out wrong or wrong enough to want to revise my original impression.

In the past, I have called the slight disturbance mentioned above a “jangle,” a term I don’t really like because it makes the response sound stronger than what it is. I suppose I could refer to it as the “error positivity response,” but that would require an explanation every time I used it.

[Edit: I have decided to solve this problem this way: A jangle is basically a trigger.  The word jangle is used rather than trigger because the word trigger normally places too much responsibility on the speaker. A jangle should be understood as an internal emotional or psychological trigger that the listener 100% owns until it has been queried about. In most cases, partners will find that their jangles largely or entirely belong to their own psychologies and not their partner’s.]

In Buddhism, a jangle is probably the second of the five skandhas—sensation.

Buddhist practice will definitely make you more aware of the second skadha or “error positivity response.”

By being aware of this response in conversation with a trusted partner, FIML practice helps us take our mindfulness to a new level by providing  us with the opportunity to ask our partner about their intentions. In this way, we check our own mental work for error.

If this is done quickly enough to preserve clear memories of 1) your “error positivity response” and 2) your partner’s memory of what was in their working memory at that moment THEN you both have one of the few psychological facts you can both be sure of.

Facts of this sort are not just psychologically of great significance, they are also of philosophical significance because they really are one of the very few fact-types you can truly know about your own idiosyncratic existence; your own very weird being.

I believe this is why the Buddha emphasized the importance of the moment.

FIML practice explodes the moment or expands it to include more reliable information (your partner’s input). And this allows both of you to do a really good analysis of what just happened, what that moment entailed.

And doing that many times, will help both of you see how you really are. It will help you break fee from erroneous psychological frames or theoretical misinterpretations of any type.

Lucid dreaming isn’t sleep or wakefulness — it’s a new state of consciousness, researchers find

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…Perception and memory processing in the lucid dreaming state were found to be different from non-lucid REM sleep. The consciousness of existing in a dream was associated with with beta waves in the right central lobe (which controls spatial awareness and nonverbal memory) and parietal lobe (which controls the sense of touch and spatial awareness). Beta waves are a type of high-frequency electromagnetic activity in the brain involved in conscious thought processes like solving problems or making decisions. Our consciousness is dominated by beta waves when we are awake.

This might explain why there is so much cognitive control in lucid dreams. Dreamers deep in REM sleep have no sense of control over factors like thoughts, feelings, and behaviors, but those in lucid dreaming states do.

…Demirel also linked gamma waves with lucid dreaming. These are the fastest brain waves, which become visible on an EEG at times when the brain is especially alert and focusing on something. When lucid dreaming begins, gamma waves increase in the right precuneus, which is involved in self-referential thinking—thoughts about ourselves and our lives. When we are awake, we often drift into this type of thinking when our minds wander.

Maybe the most mind-bending thing about lucid dreams is that they are, according to the study, similar in the brain to the effects of psychedelic drugs such as LSD and ayahuasca. These types of psychedelic experiences are also associated with the precuneus, whose activity is modified when waking imagery is seen despite having closed eyes (something usually only experienced with psychedelics).

link

Lucid dreaming and lucid sleeping are important practices in the Buddhist tradition. There is a lot of literature on it and it’s worth the time learning how to do it. For dreaming, napping in a slightly awkward position can help. I spent a year or so napping at noon on a couch with one foot on a table beside the couch, the other on the arm of the couch. That was enough to keep my bodily proprioception semi-conscious so when dreams started I was already slightly lucid. Sleeping on a bus or train is another place to practice. I had an extended period of becoming lucid during deep sleep, or so it seemed to me. Consciousness has many facets and angles. The original title of this article called lucid dreaming a ‘new’ state of consciousness. It is not new at all. It has been part of the samadhi traditions for millennia. ABN

Ben Lamm

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Ben Lamm is a serial entrepreneur and the founder and CEO of Colossal Biosciences, a company dedicated to genetic engineering and de-extinction projects. Colossal’s mission includes bringing back extinct species like the woolly mammoth and advancing conservation efforts through cutting-edge biotechnology. https://www.colossal.com

Gene editing in China:

FULL VIDEO:

The existential beauty (and chemistry) of updating beliefs

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A new study shows that updating beliefs about the world requires and stimulates dopamine release in the brain.

Lead author of the study, Matthew Nour, from University College London and Kings College London has this to say about the findings:

“We found that two key brain areas of the dopamine system (the midbrain and striatum) appear to be more active when a person updates their beliefs about the world, and this activity is related to measures of dopamine function in these regions.” (Source)

Healthy people update beliefs when new evidence is presented. The study may also show that abnormal dopamine functionality is implicated in schizophrenia and paranoid ideation by interfering with normal updating.

The study can be found here: Dopaminergic basis for signaling belief updates, but not surprise, and the link to paranoia.

I like this study because participants were measured while changing minor, short-term beliefs.

Small changes in beliefs manifested in short-term memory lies at the heart of FIML practice.

FIML relies heavily on changing inaccuracies in the short-term memory bank because this data can be isolated and objectively agreed upon by both partners and because this data is by definition fairly small and thus easily changed.

A year of FIML practice may entail a thousand or more small updates in perception, belief, and self-knowledge. Each individual update is typically small, but the aggregate of many updates over longer periods of time creates the basis for very large psychological transformations.

And since these transformations are based on more accurate data, they lead to a more realistic view of the world and the self.

Moreover, by regularly making many small updates in their perceptions of each other and themselves, FIML partners are constantly exercising their dopamine “updating system,” thus strengthening their abilities to function well in any environment.

FIML changes can come quickly, but it is long-term practice that brings the best results.

The above study shows that something very real happens when we update our perceptions. I would maintain that making this happen often with meaningful psychological information through FIML practice leads to very significant and beneficial changes in psychological functioning across many domains.

first posted October 16, 2018

A Systematic Review and New Analyses of the Gender-Equality Paradox

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Abstract

Some studies show that living conditions, such as economy, gender equality, and education, are associated with the magnitude of psychological sex differences. We systematically and quantitatively reviewed 54 articles and conducted new analyses on 27 meta-analyses and large-scale studies to investigate the association between living conditions and psychological sex differences. We found that sex differences in personality, verbal abilities, episodic memory, and negative emotions are more pronounced in countries with higher living conditions. In contrast, sex differences in sexual behavior, partner preferences, and math are smaller in countries with higher living conditions. We also observed that economic indicators of living conditions, such as gross domestic product, are most sensitive in predicting the magnitude of sex differences. Taken together, results indicate that more sex differences are larger, rather than smaller, in countries with higher living conditions. It should therefore be expected that the magnitude of most psychological sex differences will remain unchanged or become more pronounced with improvements in living conditions, such as economy, gender equality, and education.

link

Can psilocybin — the key element in magic mushrooms — be the key to treating head injuries?

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Mild repetitive head injuries do more than just cause short-term issues with cognition, behavior and motor skills. They also lead to an increased risk of dementia, Parkinson’s disease and chronic traumatic encephalopathy, and cost billions of dollars in health care.

There is no medical treatment for these types of injuries but new preliminary research out of Northeastern University shows a solution may lie in a surprising place: psilocybin, the psychedelic found in drugs like magic mushrooms.

A group of researchers including Northeastern psychology professor Craig Ferris tested the healing effects of psilocybin on adult female rats. After these rats suffered mild head injuries, researchers found that being treated with psilocybin helped restore normal brain function.

link

I usually do not put up mouse or rat studies, but this one is interesting. I myself long ago experienced enormous relief from a brain injury due to psychedelics. This feature alone may be a major factor in psychedelics beneficial effects on depression and other psychological and emotional problems. ABN

Ketamine experiment on brain recorded in detail

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I injected the horse tranquilizer Ketamine and tracked my brain data for 15 days. It completely scrambled my brain.

In a world-first we answered the question ‘what happens to the brain before, during, and after ketamine treatment?’ We also discovered how long it took for my brain to return to ‘normal’.

The results surprised me. 

link

Someday this kind of technology will assist FIML practice. I doubt it will replace it but it likely will enhance it. ABN

Intrinsic motivation is important for sustained creative activity

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A recent study shows that An insight-related neural reward signal exists and is more active in some people than in others.

This study also confirms the idea that “intrinsic motivation is important for sustained creative activity.”

Some other findings that may be of interest:

…our findings suggest that individuals who are high in reward sensitivity experience the sudden emergence of a solution into awareness as strongly rewarding whereas individuals who are low in reward sensitivity may still experience insight as sudden and attentionally salient but lacking in hedonic content.

As lifelong autodidact, I wonder if others with this marvelous “addiction” can relate to feeling almost not alive unless there is something to wonder about or figure out. I recently read a biography of Ludwig Wittgenstein. One standout was his strong tendency to seek out simple or humble environments that stimulated his mind.

…Individuals high in reward sensitivity are more likely to take drugs, develop substance-abuse disorders or eating disorders, and engage in risky behaviors such as gambling. The fact that some people find insight experiences to be highly pleasurable reinforces the notion that insight can be an intrinsic reward for problem solving and comprehension that makes use of the same reward circuitry in the brain that processes rewards from addictive drugs, sugary foods, or love.

Getting lost in the woods or on a motorcycle ride, for me, is a highly enjoyable feeling. There have to be slight tremors of fear and agitation followed by finding my way again. I suppose others may experience similar feelings in social settings or as live performers.

…These findings shed light on people’s motivations for engaging in challenging, often time-consuming, activities that potentially yield insights, such as solving puzzles or mysteries, creating inventions, or doing research. It also reinforces the notion that intrinsic motivation is important for sustained creative activity. The expectation of intrinsic rewards from comprehending and creating, rather than from an extrinsic source such as payment, is thought to be the most effective type of workplace motivation…

A society with universal basic income in which no one has to work unless they want to might bring about the greatest flourishing of human talent ever. Then again, maybe not. Inspiration does need a stick on the back sometimes and “joy has no children,” meaning happiness produces few inventions.

Here’s an article about the study: Aha! + Aaaah: Creative Insight Triggers a Neural Reward Signal.

first posted April 10, 2020

Origin of cultural learning: babies imitate because they are imitated

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For the study, the researchers looked at the interaction between mother and child over several months. The babies came into the lab for the first time at the age of 6 months, while their final visit was when they were 18 months old. As they engaged in various play situations, the interactions and imitations of mother and child were analyzed.

The longitudinal study shows that the more sensitive a mother was in her interactions with her six-month-old child and the more often she imitated the infant, the greater the child’s ability was at the age of 18 months to imitate others.

In the interaction between parents and child, mutual imitation is a sign of communication. Parents respond to the signals given by the child and reflect and amplify them. A mutual imitation of actions and gestures develops. “These experiences create connections between what the child feels and does on the one hand and what it sees on the other. Associations are formed. The child’s visual experience is connected to its own motor activity,” says Markus Paulus, explaining the neuro-cognitive process.

Children learn a variety of skills through imitation, such as how to use objects, cultural gestures like waving, and the acquisition of language. “Children are incredible imitators. Mimicry paves the way to their further development. Imitation is the start of the cultural process toward becoming human,” says Markus Paulus. In psychology, the theory that the ability to imitate is inborn held sway for a long time. The LMU study is further evidence that the ability is actually acquired.

source

Mutual imitation and/or rapport are fundamental to interpersonal communication and a constant of it. FIML practice is a metacognitive method for making these processes ‘objective’ and thus mutually understandable, analyzable, and correctable or transformable as needed or desired. FIML works with objective material, which is defined as material both partners agree on. Real-world, real-time mutually agreed upon moments of micro communication discovered during FIML practice are some of the best objective psychological material you will ever acquire. Analyzing it with your partner is a total blast! There is no other way to do it except through FIML practice. ABN

UPDATE: This study reveals the profound importance of imitation for the infant brain. Imitation is one of the first things humans learn and it establishes a basis for social interactions from then on. Imitation is a major foundation of all cultures. People within any culture always imitate each other a lot. This includes adults who form new cultures or conform to deep transitions within their already accepted cultures. Often, cultural transitions are so large, the original culture is lost to time. This instinct to keep up with the group through imitation is a major factor in behavioral mind-control. This video provides an excellent example of how blunt, crude, nasty and deeply fear-based mind-controlled cultural transitions often are. Not only are viewers lured into being terrified of the invisible virus, they are also bullied into conforming to the one and only way to save themselves—taking a dangerous and untested vax. When children and then babies were also sucked into this whirlpool of anti-science, all morality was gone and all that was left was fear and insane conformity. If the mind-controllers learned anything from this, they will probably leave pregnant women and babies alone next time. More likely is they will cause even greater fear. ABN

Long-Term Cannabis Use and Cognitive Function: Findings from a Longitudinal Study

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A recently published study examined the effects of cannabis use on age-related cognitive function in adults. Noting the limited number of studies in this area compared to studies on cannabis use and short-term cognition, the researchers sought to examine the relationship between cannabis use from early adulthood to late midlife and cognitive decline. The study, “Cannabis Use and Age-Related Changes in Cognitive Function From Early Adulthood to Late Midlife in 5162 Danish Men,” was published in November 2024 in Brain and Behavior.

This study examined data from 5162 Danish men born between 1949-1961 who had participated in assessments on cognitive aging and in follow-up questionnaires. Data from the Danish Aging and Cognition (DanACo) cohort was used, which was administered when the mean age of the participants was 20. The follow up questionnaires covered socioeconomic, lifestyle, and health-related factors and was administered when the mean age of the participants was 64.

…Ultimately, the study concluded that, “Men with a history of cannabis use had less cognitive decline from early adulthood to late midlife compared to men without a history of cannabis use. Among cannabis users, neither age of initiation of cannabis use nor frequent use was significantly associated with a greater age-related cognitive decline.”

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