Understanding the exceptional pre-vaccination Era East Asian COVID-19 outcomes

Abstract

During the first year of the pandemic, East Asian countries have reported fewer infections, hospitalizations, and deaths from COVID-19 disease than most countries in Europe and the Americas. Our goal in this paper is to generate and evaluate hypothesis that may explain this striking fact. We consider five possible explanations: (1) population age structure (younger people tend to have less severe COVID-19 disease upon infection than older people); (2) the early adoption of lockdown strategies to control disease spread; (3) genetic differences between East Asian population and European and American populations that confer protection against COVID-19 disease; (4) seasonal and climactic contributors to COVID-19 spread; and (5) immunological differences between East Asian countries and the rest of the world. The evidence suggests that the first four hypotheses are unlikely to be important in explaining East Asian COVID-19 exceptionalism. Lockdowns, in particular, fail as an explanation because East Asian countries experienced similarly good infection outcomes despite vast differences in lockdown policies adopted by different countries to control the COVID-19 epidemic. The evidence to date is consistent with our fifth hypothesis – pre-existing immunity unique to East Asia – but there are still essential parts of this story left for scientists to check.

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The Ethical Skeptic has been saying this for a long time and also claims that China suppressed information that covid was circulating in China much earlier than Fall of 2019. A speculative line of thought leading from this and other evidence is that China inoculated its own population in 2017-18 with a mild covid variant in preparation for releasing the covid bioweapon on the world—and particularly USA—in late 2019. See this for more on this topic: Military thought experiment Part 4: Did China already do it? ABN

Thirty-two covid ‘crypto variants’ detected in 13 states

More than 30 extremely mutated, never-before-seen Covid strains are lurking in multiple US states, DailyMail.com can reveal. 

A team of scientists from the University of Missouri has been tracking these so-called ‘cryptic’ variants by testing wastewater samples across the country.

They have detected 32 strains so far in 13 states — including New York, California and Florida — but say these cases are just the ‘tip of the iceberg’.

The viruses are being harbored by people known as ‘long-haulers’, patients who struggle to clear Covid infection for months or even years, giving the virus an unusually long window to mutate.

Dr Marc Johnson, the virologist at Missouri who is leading the research, warned the strains are so mutated they would instantly be classed ‘variants of concern’ if they were to start spreading.

He believes that one in every 4million people are harboring one of these strains, or have in the past. This would mean there are about 80 cryptic lineages circulating.

So far, ten have been detected in New York City —  more than double any individual state.

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CHOLESTEROL, TESTOSTERONE, AND THE WAR AGAINST MASCULINITY — Dr Simon Goddek

There are 5 classes of steroid hormones: testosterone (androgen), estradiol (estrogen), progesterone (progestin), cortisol/corticosterone (glucocorticoids), and aldosterone (mineralocorticoid). Testosterone and its most potent metabolite, dihydrotestosterone (DHT), progesterone, and estradiol are classified as sexual steroids, while cortisol/corticosterone and aldosterone are collectively referred to as corticosteroids.

Sexual steroids are essential for the body’s development and proper functioning. They regulate sexual differentiation, the emergence of secondary sexual characteristics, sexual behavior patterns, and reproduction. The production of these steroids follows sexual dimorphism, involving differences not only in hormonal action but also in regulation and temporal patterns of production. However, they all depend on a strategic chemical substance: cholesterol.

Since cholesterol cannot be dissolved in the blood, it is “carried” through the body using a “transportation medium” called lipoprotein – which is essentially cholesterol with a protein coating. In humans, we find two types of lipoproteins doing this job: low-density lipoprotein (LDL) and high-density lipoprotein (HDL).

All steroid hormones are produced using cholesterol from a common precursor (pregnenolone) formed by the enzymatic cleavage of a 6-carbon side chain from the 27-carbon cholesterol molecule. This reaction is catalyzed by the cytochrome P450 cleavage enzyme (P450scc, CYP11A1) at the mitochondrial level.

Tissues that produce steroid hormones capture cholesterol from 4 main sources: (1) Cholesterol synthesized by the body from acetate; (2) Cholesterol harvested from HDL and LDL; (3) Cholesterol derived from the hydrolysis of cholesterol ester deposits; and (4) Cholesterol internalized by the plasma membrane.

Although the 3 main steroid-producing organs (adrenal, testicles, and ovaries) can produce cholesterol under the influence of certain hormones, the adrenals and ovaries preferentially use cholesterol captured directly from the bloodstream.

Foods, drugs, and toxins that interfere with mitochondrial function or the body’s ability to maintain good cholesterol reserves (or sustain healthy circulating cholesterol levels) will ultimately undermine your sexual hormone levels – especially testosterone.

This leads me to question to what extent the “war on cholesterol” is not just a disguise for the many faces of the notorious “war on masculinity” that has fiercely plagued the West for the past 5 decades.

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McKernan to Couey — ‘Wuhan might be a scapegoat lab and many others had similar leaks that we never saw until PCR was turned on’

1st- I agree with @jjcouey on 99% of what’s going on and we find ourselves ever whittling away at our minor differences.
Since this is a testimony, I feel obligated to point out the inconsistencies.
1:30 mins in he shows a paper where the Infectious clone..

Produces the exact same imbalance in gRNA to sgRNA once it is executed in a cell.

His own words states, they made an IC and only get 2 copies of the full length genome.

So what is the mechanism by which these ICs generate higher copy number of gRNA/sgRNA?

This is never described.

[This is detailed material but interesting if you have paid attention to either of these two excellent researchers. It may look like there is a fine line between them but the difference is a large ongoing military psyop complete with timed releases of covid Infectious Clones (IC) or not. ABN]

Continue reading “McKernan to Couey — ‘Wuhan might be a scapegoat lab and many others had similar leaks that we never saw until PCR was turned on’”

Pfizer covid vax contains an SV40 sequence which is a known promoter of cancer virus — Tokyo University professor

Dr Meryl Nass interview; hassled in Maine

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Dr. Nass had her license suspended for “Covid misinformation,” after she didn’t go all in on the vaccine like the Mills administration demanded. In this fascinating interview, we take a deep dive into her story over the last 3 years, and how the Mills administration tried to make an example out of her to clamp down on any resistance in the medical community.

Influence of cannabis use on incidence of psychosis in people at clinical high risk

Abstract

Aims: Evidence for case-control studies suggests that cannabis use is a risk factor for the development of psychosis. However, there have been limited prospective studies and the direction of this association remains controversial. The primary aim of the present study was to examine the association between cannabis use and the incidence of psychotic disorders in people at clinical high risk of psychosis. Secondary aims were to assess associations between cannabis use and the persistence of psychotic symptoms, and with functional outcome.

Methods: Current and previous cannabis use were assessed in individuals at clinical high risk of psychosis (n=334) and healthy controls (n=67), using a modified version of the Cannabis Experience Questionnaire. Participants were assessed at baseline and followed up for 2 years. Transition to psychosis and persistence of psychotic symptoms were assessed using the Comprehensive Assessment of At-Risk Mental States criteria. Level of functioning at follow up was assessed using the Global Assessment of Functioning disability scale.

Results: During follow up, 16.2% of the clinical high-risk sample developed psychosis. Of those who did not become psychotic, 51.4% had persistent symptoms and 48.6% were in remission. There was no significant association between any measure of cannabis use at baseline and either transition to psychosis, the persistence of symptoms, or functional outcome.

Conclusions: These findings contrast with epidemiological data that suggest that cannabis use increases the risk of psychotic disorder. This article is protected by copyright. All rights reserved.

Keywords: THC; clinical high-risk; longitudinal; psychotic disorders; substance use.

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Ethical Skeptic ending weekly dashboard

Now that we are down to less than 50 K cases per week, time to cease the weekly case dashboard. In this endeavor we have established 5 things without a shadow of a doubt:

1. There is more than one lineage of Covid active at any given time – some mimic a normal HCoV cold in terms of impact, and could easily have slipped by in 2018/19.

2. Covid lineages go into and out of dormancy (Omicron did not just magically appear with 7 years of mutation under its belt, in 2 months of existence)

3. Courses arrive and depart conforming to a Gompertz function, naturally.

4. Natural immunity is 20+ times stronger than any putative effect from the vaccine. We were forced by social media to lie about this, and this cost an as-yet-undetermined level of younger person death.

5. The vaccinated were 2.6 times more likely to be infected by the last (vaccine-appetite) courses of Covid. These will go into dormancy and will come back, so this is not over, especially for the now immune system impaired.

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Originally tweeted by Ethical Skeptic ☀ (@EthicalSkeptic) on April 24, 2023.

Reply to Ethical Skeptic

If you’re curious I’ll tag you in interviews I just did that are hitting larger media. McKernan’s plasmid discovery confirms: LNP shifted electronegative (zeta) with plasmid addition to LNP (leaks into vascular) and if RNA leak out goes to lungs and plasmid+nucleus= turbo cancer.

2/The plasmids are very negatively charged. They weren’t purified out of the RNA when they formed the LNP. Vascular system. But it LNP degrade, RNA leak out, pushes POSITIVE net charge on whole LNP: goes to lungs (spike expression overload). Plasmid+cation lipid hit nucleus. :(

3/Also I just retweeted chief nerd’s post of Dr Hazan speaking to gut bacteria and I found a 2021 study I posted stating that if Bacteria overexpress a protein (spike) they commit harakiri/sepukku and self distruct. Causing microbrial resistance too. Buckle up. Gonna get worse.

4/to clarify, If DNA plasmid enter LNP, the zeta goes from -3 mV to insanely more negative, which would cause it (caracca et al) leak into vascular system even if aspirating. The negative charge attracts HARD to platelet (positive) and will cause adverse events plus amplification

5/highly negative charge on the LNP can drive it to blood vessels arteries heart. Also cause allergic reaction. Unwanted immunogenic response. Massive cytokine storm. Clotting with acceleration of coagulation events. It’s just luck of the draw who gets the charged LNP/plasmids.

6/ I’m sorry. :(

Originally tweeted by Christie Laura Grace (@_HeartofGrace_) on April 23, 2023.

This is the most interesting reply to TES I have seen during all of covid. I hope he sees it and responds. A conversation between these two would be very interesting. ABN

UPDATE FROM TES: